MovDisordV3, France, Analysis, bibRecord, 000003

Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.

Identifieur interne : 000003 ( France/Analysis ); précédent : 000002; suivant : 000004

Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.

Auteurs : Carole Carcenac [France] ; Mathieu Favier ; Yvan Vachez ; Emilie Lacombe ; Sébastien Carnicella ; Marc Savasta ; Sabrina Boulet

Source :

Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.

RBID : pubmed:25588931

Abstract

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment for the motor symptoms of Parkinson's disease (PD), but its mechanisms, particularly as concern dopaminergic transmission, remain unclear. The aim of this study was to evaluate changes in the expression of dopaminergic receptors (D1 , D2 , and D3 receptors) after prolonged (4 h) unilateral STN-HFS in anesthetized intact rats and rats with total dopaminergic denervation. We used [(3) H]SCH 23390, [(125) I]iodosulpride, and [(125) I]OH-PIPAT to assess the densities of D1 R, D2 R, and D3 R, respectively, within different areas of the striatum-a major input structure of the basal ganglia-including the nucleus accumbens. We found that STN-HFS increased D1 R levels in almost all of the striatal areas examined, in both intact and denervated rats. By contrast, STN-HFS led to a large decrease in D2 R and D3 R levels, limited to the nucleus accumbens and independent of the dopaminergic state of the animals. These data suggest that the influence of STN-HFS on striatal D1 R expression may contribute to its therapeutic effects on motor symptoms, whereas its impact on D2 R/D3 R levels in the nucleus accumbens may account for the neuropsychiatric side effects often observed in stimulated PD patients, such as postoperative apathy. © 2015 International Parkinson and Movement Disorder Society.

DOI: 10.1002/mds.26146
PubMed: 25588931

Affiliations:

Links to Exploration step

pubmed:25588931

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.</title>
<author><name sortKey="Carcenac, Carole" sort="Carcenac, Carole" uniqKey="Carcenac C" first="Carole" last="Carcenac">Carole Carcenac</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, Grenoble Institut des Neurosciences, Dynamique et Physiopathologie des Ganglions de la Base, Grenoble, France; Grenoble University, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Grenoble Institut des Neurosciences, Dynamique et Physiopathologie des Ganglions de la Base, Grenoble, France; Grenoble University, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Favier, Mathieu" sort="Favier, Mathieu" uniqKey="Favier M" first="Mathieu" last="Favier">Mathieu Favier</name>
</author>
<author><name sortKey="Vachez, Yvan" sort="Vachez, Yvan" uniqKey="Vachez Y" first="Yvan" last="Vachez">Yvan Vachez</name>
</author>
<author><name sortKey="Lacombe, Emilie" sort="Lacombe, Emilie" uniqKey="Lacombe E" first="Emilie" last="Lacombe">Emilie Lacombe</name>
</author>
<author><name sortKey="Carnicella, Sebastien" sort="Carnicella, Sebastien" uniqKey="Carnicella S" first="Sébastien" last="Carnicella">Sébastien Carnicella</name>
</author>
<author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name>
</author>
<author><name sortKey="Boulet, Sabrina" sort="Boulet, Sabrina" uniqKey="Boulet S" first="Sabrina" last="Boulet">Sabrina Boulet</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2015">2015</date>
<idno type="doi">10.1002/mds.26146</idno>
<idno type="RBID">pubmed:25588931</idno>
<idno type="pmid">25588931</idno>
<idno type="wicri:Area/PubMed/Corpus">000292</idno>
<idno type="wicri:Area/PubMed/Curation">000292</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000057</idno>
<idno type="wicri:Area/Ncbi/Merge">004217</idno>
<idno type="wicri:Area/Ncbi/Curation">004217</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004217</idno>
<idno type="wicri:Area/Main/Merge">000057</idno>
<idno type="wicri:Area/Main/Curation">000057</idno>
<idno type="wicri:Area/Main/Exploration">000057</idno>
<idno type="wicri:Area/France/Extraction">000003</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.</title>
<author><name sortKey="Carcenac, Carole" sort="Carcenac, Carole" uniqKey="Carcenac C" first="Carole" last="Carcenac">Carole Carcenac</name>
<affiliation wicri:level="1"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, Grenoble Institut des Neurosciences, Dynamique et Physiopathologie des Ganglions de la Base, Grenoble, France; Grenoble University, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Grenoble Institut des Neurosciences, Dynamique et Physiopathologie des Ganglions de la Base, Grenoble, France; Grenoble University, Grenoble</wicri:regionArea>
<placeName><settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Favier, Mathieu" sort="Favier, Mathieu" uniqKey="Favier M" first="Mathieu" last="Favier">Mathieu Favier</name>
</author>
<author><name sortKey="Vachez, Yvan" sort="Vachez, Yvan" uniqKey="Vachez Y" first="Yvan" last="Vachez">Yvan Vachez</name>
</author>
<author><name sortKey="Lacombe, Emilie" sort="Lacombe, Emilie" uniqKey="Lacombe E" first="Emilie" last="Lacombe">Emilie Lacombe</name>
</author>
<author><name sortKey="Carnicella, Sebastien" sort="Carnicella, Sebastien" uniqKey="Carnicella S" first="Sébastien" last="Carnicella">Sébastien Carnicella</name>
</author>
<author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name>
</author>
<author><name sortKey="Boulet, Sabrina" sort="Boulet, Sabrina" uniqKey="Boulet S" first="Sabrina" last="Boulet">Sabrina Boulet</name>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2015" type="published">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment for the motor symptoms of Parkinson's disease (PD), but its mechanisms, particularly as concern dopaminergic transmission, remain unclear. The aim of this study was to evaluate changes in the expression of dopaminergic receptors (D1 , D2 , and D3 receptors) after prolonged (4 h) unilateral STN-HFS in anesthetized intact rats and rats with total dopaminergic denervation. We used [(3) H]SCH 23390, [(125) I]iodosulpride, and [(125) I]OH-PIPAT to assess the densities of D1 R, D2 R, and D3 R, respectively, within different areas of the striatum-a major input structure of the basal ganglia-including the nucleus accumbens. We found that STN-HFS increased D1 R levels in almost all of the striatal areas examined, in both intact and denervated rats. By contrast, STN-HFS led to a large decrease in D2 R and D3 R levels, limited to the nucleus accumbens and independent of the dopaminergic state of the animals. These data suggest that the influence of STN-HFS on striatal D1 R expression may contribute to its therapeutic effects on motor symptoms, whereas its impact on D2 R/D3 R levels in the nucleus accumbens may account for the neuropsychiatric side effects often observed in stimulated PD patients, such as postoperative apathy. © 2015 International Parkinson and Movement Disorder Society.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<settlement><li>Grenoble</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Boulet, Sabrina" sort="Boulet, Sabrina" uniqKey="Boulet S" first="Sabrina" last="Boulet">Sabrina Boulet</name>
<name sortKey="Carnicella, Sebastien" sort="Carnicella, Sebastien" uniqKey="Carnicella S" first="Sébastien" last="Carnicella">Sébastien Carnicella</name>
<name sortKey="Favier, Mathieu" sort="Favier, Mathieu" uniqKey="Favier M" first="Mathieu" last="Favier">Mathieu Favier</name>
<name sortKey="Lacombe, Emilie" sort="Lacombe, Emilie" uniqKey="Lacombe E" first="Emilie" last="Lacombe">Emilie Lacombe</name>
<name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name>
<name sortKey="Vachez, Yvan" sort="Vachez, Yvan" uniqKey="Vachez Y" first="Yvan" last="Vachez">Yvan Vachez</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Carcenac, Carole" sort="Carcenac, Carole" uniqKey="Carcenac C" first="Carole" last="Carcenac">Carole Carcenac</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/France/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000003 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000003 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    MovDisordV3
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     pubmed:25588931
   |texte=   Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/France/Analysis/RBID.i   -Sk "pubmed:25588931" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/France/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a MovDisordV3

This area was generated with Dilib version V0.6.23.
Data generation: Sun Jul 3 12:29:32 2016. Site generation: Wed Feb 14 10:52:30 2024

Movement Disorders (revue)

Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.

Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.